![]() 3Īt therapeutic doses of isosorbide mononitrate, nitric oxide has a bigger effect on larger muscular arteries over small resistance arteries. 7 In healthy subjects, the stroke volume is decreased and venous pooling can occur in the standing posture, leading to postural hypotension and dizziness. 3 Nitric oxide works on both arteries and veins, but predominantly veins: by relaxing veins and reducing the central venous pressure, nitric oxide causes venous pooling and a decrease in the venous return to the heart, thus decreasing cardiac preload. The pharmacological action is mediated by the active metabolite, nitric oxide, which is released when isosorbide mononitrate is metabolized. Isosorbide mononitrate is an anti-anginal agent and vasodilator that relaxes vascular smooth muscle to prevent and manage angina pectoris. 7 Type Small Molecule Groups Approved Structure The extended-release forms of the drug are also available generically and under the brand name Imdur. 4 It is available in oral tablets generically and under the brand name ISMO and Monoket. ![]() 3įirst approved by the FDA in 1991, 7 isosorbide mononitrate is used for the prevention and management of angina pectoris caused by coronary artery disease however, the onset of action of orally-administered isosorbide mononitrate is not rapid enough to offset an acute anginal episode. 7 Isosorbide mononitrate has a longer duration of action than nitroglycerin due to its slow onset of absorption and metabolism. Like other organic nitrates, isosorbide mononitrate acts as a prodrug for its active metabolite, nitric oxide, which mediates the therapeutic action of isosorbide mononitrate. 4, 7 Isosorbide mononitrate is an active metabolite of isosorbide dinitrate. ![]() It is an anti-anginal agent that works by relaxing the smooth muscles of both arteries and veins, but but predominantly veins to reduce cardiac preload. Isosorbide mononitrate is an organic nitrate with vasodilating properties. Imdur, Ismo, Monoket Generic Name Isosorbide mononitrate DrugBank Accession Number DB01020 Background ![]()
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